Sometimes I wonder if the people who write textbooks get off on sneaking in random digs or inside jokes just to see if anyone ever actually reads full sentences anymore. Especially under dazzling headings like, "Classifying 5-HT1 Receptors".
Maybe I really need to get out more but when I came across this line from Rang and Dale's Pharmacology text, it made me chuckle:
"The cerebral vessels are unusual in that vasoconstriction is mediated by 5-HT1 receptors; in most vessels, 5-HT2 receptors are responsible. The hapless '5-HT1C' receptor-actually the first to be cloned -has been officially declared non-existent, having been ignominiously reclassified as the 5-HT2C receptor when it was found to be linked to inositol trisphosphate production rather than adenylate cyclase." [my bold]
The tone of that makes it sound like the
genius idiot that CLONED a RECEPTOR and then mistakenly classified it is forced to remain in his apartment and order his groceries online because of his atrocious pharmacological blunder. I mean, everyone knows it wasn't linked to adenylate cyclase. How embarrassing.
Ok, I do need to get out more.