Sunday, May 15, 2011

How Pharmacologists Bitch Slap

Sometimes I wonder if the people who write textbooks get off on sneaking in random digs or inside jokes just to see if anyone ever actually reads full sentences anymore. Especially under dazzling headings like, "Classifying 5-HT1 Receptors". 

Maybe I really need to get out more but when I came across this line from Rang and Dale's Pharmacology text, it made me chuckle:

"The cerebral vessels are unusual in that vasoconstriction is mediated by 5-HT1 receptors; in most vessels, 5-HT2 receptors are responsible. The hapless '5-HT1C' receptor-actually the first to be cloned -has been officially declared non-existent, having been ignominiously reclassified as the 5-HT2C receptor when it was found to be linked to inositol trisphosphate production rather than adenylate cyclase." [my bold]

The tone of that makes it sound like the genius idiot that CLONED a RECEPTOR and then mistakenly classified it is forced to remain in his apartment and order his groceries online because of his atrocious pharmacological blunder. I mean, everyone knows it wasn't linked to adenylate cyclase. How embarrassing. 

 Ok, I do need to get out more.


Anonymous said...

There's also one in Human Histology:

The first lymphoma was described by Thomas Hodgkin and this specific type has subsequently been named Hodgkin’s lymphoma. Thus, the main categories of lymphoma are
Hodgkin’s lymphoma and, with the wit and intellectual rigor for which pathologists are renowned,
Non-Hodgkin’s lymphoma.

(Human Histology, Stevens & Lowe, page 144)

Anonymous said...

I feel research scientists MUST get into petty sqaubbles like that all the time.

"Say, did you hear what Johnson did? He thought he was identifying a JAK-2 Kinase, when in fact, it was a RECEPTOR Tyrosine Kinase. What a knob!"

Albinoblackbear said...

CT--That. Is. Awesome!!! hahahah

Thanks for that!!

IANH-Yeah exactly my point. You know Rang had some random bone to pick with 5HT2 receptor guy. Like he got the grant that Rang didn't get in grad school or something...