With regards to drug treatment options for rheumatoid arthritis:
"The antirheumatoid action of most of these agents was usually discovered through a mixture of serendipity and clinical intuition. When the drugs were introduced, nothing was known about their mechanism of action in these conditions, and decades of in vitro experiments have generally resulted in further bewilderment rather than understanding."
-Rang and Dale's Pharmacology, 6th ed. (2009)
I like the honesty in the statement, though it isn't overly reassuring considering the amount these drugs are prescribed. I guess that a lot of medicine is just knowing that it works, not necessarily knowing how it works...but no ones seems to want to admit that.